에스트로젠과 프로게스테론이 골모세포의 증식과 활성에 미치는 영향
Effects of Estrogen and Progesterone on the Proliferation and Activity of Osteoblastic cells Abstract
하국봉, 김세원, 손우성,
소속 상세정보
하국봉 ( ) - 부산대학교 치과대학 교정학교실
김세원 ( ) - 단국대학교 치과대학 치과약리학교실
손우성 ( ) - 부산대학교 치과대학 교정학교실
KMID : 0361920010310020237
Abstract
Biomechanical reactions of tooth movement are the combination of bone formation and resorption, in which many paracrine factors are involved. The sex hormone is one of the paracrine factors and the sex hormonal level of an adult female varies according to the body condition, e.g. mensturation, pregnancy, postmenopause, etc. Although the exact mechanism is not clarified yet, estrogen and progesterone are known to regulate the function of osteoblast. Again osteoblast is reported to affect the function of osteoclast. The purpose of this study is to determine the influence of the female sex hormone, estrogen and progesterone, on the cell proliferation and activity of HOS and ROS17/2.8 cell line.
The observed results were as follows.
1. Estrogen inhibited HOS cell proliferation and promoted ROS17/2.8 cell proliferation.
2. Estrogen increased the activity of alkaline phosphatase of HOS cell and reduced the activity of alkaline phosphatase of ROS17/2.8 cell.
3. Progesterone inhibited the proliferation of HOS and ROS17/2.8 cell, but had no influence on the activity of alkaline phosphatase.
4. Estrogen and progeterone_ did not have any particular effects on the activity of super oxide, nitric oxide and gelatinase of HOS and ROS17/2.8 cell.
키워드
에스트로젠;프로게스테론;골모세포;MTT;alkaline phosphatase;nitrite;NBT;gelatinase;Progesterone;Estrogen;Osteoblast;MTT;Alkaline phosphatase;Nitrite NBT gelatinase
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